abstract：:Matrix metalloproteinases (MMPs) play an important role in tumor invasion and metastasis. Enhanced expression of matrix metalloproteinase-2 (MMP-2) has been demonstrated in dermatofibroma (DF) and malignant fibrous histiocytoma (MFH). MMP-2 has been shown to be activated by membrane-type MMPs (MT-MMPs). To study the r...

journal_title：Journal of dermatological science

authors： Ohnishi Y,Ito Y,Tajima S,Ishibashi A,Arai K

更新日期：2002-02-01 00:00:00

abstract：:Large numbers of pigmented melanocytes are located in human hair follicles, predominantly around the dermal papillae, and the number of melanocytes and the melanogenic activity of the hair follicles are closely related to the hair cycle. We found that cultured human dermal papilla cells secreted a melanocyte chemoattr...

journal_title：Journal of dermatological science

authors： Ideta R,Soma T,Tsunenaga M,Ifuku O

更新日期：2002-01-01 00:00:00

abstract：:We previously showed that 12-O-tetradecanoylphorbol-13-acetate (TPA) and Ca2+-switch from low (0.07 mM) to normal (1.87 mM) concentration in culture medium, which were also linked to activation of protein kinase C (PKC), lead to phosphorylation of 180 kDa-bullous pemphigoid antigen (BPAG) 2, but not of 230 kDa-BPAG1, ...

journal_title：Journal of dermatological science

authors： Matsuoka Y,Yamada T,Seishima M,Hirako Y,Owaribe K,Kitajima Y

更新日期：2001-11-01 00:00:00

abstract：:Temperature influences the stratum corneum adsorption of several topically applied compounds. This study was designed to evaluate the influence of the temperature on the stratum corneum adsorption of 3 UV filters. The UV filters were solubilized in two vehicles, an emulsion gel and petroleum jelly and applied at respe...

journal_title：Journal of dermatological science

authors： Clarys P,Gabard B,Lambrecht R,Barel A,Bieli E,Lüdi S

更新日期：2001-10-01 00:00:00

abstract：:Nevoid basal cell carcinoma syndrome (NBCCS) is an autosomal dominant disorder characterized by developmental and skeletal anomalies, palmo-plantar pits, odontogenic keratocysts, ectopic calcification, and occurrence of various types of tumors including basal cell carcinoma. Recent evidence has indicated that the huma...

journal_title：Journal of dermatological science

authors： Minami M,Urano Y,Ishigami T,Tsuda H,Kusaka J,Arase S

更新日期：2001-09-01 00:00:00

abstract：:Our previous study reported that advanced glycation end-products (AGE)-modified BSA produced active oxygen species, *O2-, H2O2, and *OH under UVA irradiation and enhanced the cytotoxicity of UVA light. We examined whether pentosidine in AGE-modified BSA was involved in one of the mechanisms generating the active oxyge...

journal_title：Journal of dermatological science

authors： Okano Y,Masaki H,Sakurai H

更新日期：2001-08-01 00:00:00

abstract：:Flank organs of male Golden Syrian hamsters contain sebaceous glands and hair follicles whose morphology and function are highly dependent on androgen, which makes these organs a useful model to study androgen action. In order to investigate molecular mechanisms of androgen action, we cloned a cDNA encoding the hamste...

journal_title：Journal of dermatological science

authors： Shiba K,Hamaguchi T,Kataoka K,Yamaguchi Y,Handa H,Adachi K

更新日期：2001-07-01 00:00:00

abstract：:Systemic sclerosis (SSc) is a connective tissue disease with unknown etiology characterized by excessive deposition of collagen in the skin as well as various internal organs. One of the characteristic histological features is the presence of infiltrating mononuclear cells in the dermis in its early stage. As well as ...

journal_title：Journal of dermatological science

authors： Yamamoto T,Eckes B,Hartmann K,Krieg T

更新日期：2001-06-01 00:00:00

abstract：:The CC-chemokine TARC is known to be a ligand for the CCR4 receptor which in turn is known to be expressed selectively on the Th(2)-subset of lymphocytes. Atopic dermatitis is generally believed to be a Th(2)-type disease, and TARC has been shown to be expressed in the skin lesions of a murine model of AD. IL-10 is an...

journal_title：Journal of dermatological science

authors： Vestergaard C,Kirstejn N,Gesser B,Mortensen JT,Matsushima K,Larsen CG

更新日期：2001-05-01 00:00:00

abstract：:Langerhans cells are dendritic cells situated in the mammalian epidermis. In human epidermis, the concentration is between 460 and 1000 mm(-2). Langerhans cells fulfill an essential role in skin immune responses. Numerous scientific reports on Langerhans cells have appeared, but with no systematic research on the patt...

journal_title：Journal of dermatological science

authors： Numahara T,Tanemura M,Nakagawa T,Takaiwa T

更新日期：2001-04-01 00:00:00

abstract：:SV-40 transformed human keratinocytes (SVHK cells) were stimulated with epidermal growth factor (EGF) and ultraviolet B (UVB) irradiation. Following the stimulation, cell growth, apoptosis, and the activities of mitogen-activated protein (MAP) kinase families were analyzed. EGF (100 ng/ml) increased SVHK cell number c...

journal_title：Journal of dermatological science

authors： Nakamura S,Takahashi H,Kinouchi M,Manabe A,Ishida-Yamamoto A,Hashimoto Y,Iizuka H

更新日期：2001-02-01 00:00:00

abstract：:To clarify the behavioral and pathological features of spontaneous scratching of NC mice with mite-induced chronic dermatitis, we investigated the spontaneous and pruritogen-evoked scratching of NC mice. Although the frequency of scratching of NC mouse did not increase under specific pathogen-free environment, it grad...

journal_title：Journal of dermatological science

authors： Yamaguchi T,Maekawa T,Nishikawa Y,Nojima H,Kaneko M,Kawakita T,Miyamoto T,Kuraishi Y

更新日期：2001-01-01 00:00:00

abstract：:It was previously reported that peripheral blood mononuclear cells (PBMC) from the patients with psoriasis vulgaris (PV) showed a reduced proliferative response in vitro to the stimulation of a lyophilized preparation of penicillin-treated low virulence Su-strain of Streptococcus pyogenes group 3, OK-432. In this stud...

journal_title：Journal of dermatological science

authors： Takahashi K,Aiba S,Uddin Z,Kasai H,Tagami H

更新日期：2001-01-01 00:00:00

abstract：:As we contemplate the nature of life sciences in the 21st century, we should briefly consider the changes that have occurred in the past century. Surely, the sources of progress of this science in the next century are the advances emerging now. Furthermore, the likely pace of discovery and change in life sciences in t...

journal_title：Journal of dermatological science

authors： Sharp PA

更新日期：2000-12-01 00:00:00

abstract：:The vasculature in adult skin remains normally quiescent, due to the dominant influence of endogenous angiogenesis inhibitors over angiogenic stimuli. However, skin retains the capacity for brisk initiation of angiogenesis, the growth of new blood vessels from preexisting vessels, during tissue repair and in numerous ...

journal_title：Journal of dermatological science

authors： Detmar M

更新日期：2000-12-01 00:00:00

abstract：:Epidermolysis bullosa simplex associated with late onset of muscular dystrophy has been found to show defective expression of plectin, an intracytoplasmic protein in hemidesmosomes. In this report, we examined ability of cell-to-matrix attachment of cultured keratinocytes derived from a case with this disease by vario...

journal_title：Journal of dermatological science

authors： Kurose K,Mori O,Hachisuka H,Shimizu H,Owaribe K,Hashimoto T

更新日期：2000-12-01 00:00:00

abstract：:We examined the production of superantigenic exotoxins in 136 coagulase-negative staphylococci isolated from various skin lesions in humans using a reversed passive latex agglutination test (Denka Seiken). As a control we examined the same in 50 Staphylococcus aureus strains isolated from non-infective skin ulcers in ...

journal_title：Journal of dermatological science

authors： Akiyama H,Yamasaki O,Tada J,Arata J

更新日期：2000-11-01 00:00:00

abstract：:We examined the adherence characteristics and susceptibility to various antimicrobial agents of 130 strains of Staphylococcus aureus isolated from infective skin lesions and 135 strains of S. aureus isolated from non-infective eczematous lesions of atopic dermatitis (AD) patients. The isolation rate of methicillin-res...

journal_title：Journal of dermatological science

authors： Akiyama H,Yamasaki O,Tada J,Arata J

更新日期：2000-08-01 00:00:00

abstract：:Two different melanocyte-specific mRNAs are studied as markers for circulating melanoma cells in vitro using the human melanoma cell line G361 and in vivo using blood samples from Japanese melanoma patients at different clinical stages. These mRNAs encode tyrosinase, the most essential enzyme for melanin synthesis, an...

journal_title：Journal of dermatological science

authors： Tsukamoto K,Ueda M,Hirata S,Osada A,Kitamura R,Takahashi T,Ichihashi M,Shimada S

更新日期：2000-06-01 00:00:00

abstract：:It has been reported that cellular oxidative stress induces apoptosis. Ultraviolet radiation that generates reactive oxygen intermediates (ROIs) also induces apoptosis. Superoxide dismutase (SOD) is among the most active scavengers of ROIs, providing defense against the cellular oxidative stress. Mammalian cells expre...

journal_title：Journal of dermatological science

authors： Takahashi H,Hashimoto Y,Aoki N,Kinouchi M,Ishida-Yamamoto A,Iizuka H

更新日期：2000-05-01 00:00:00

abstract：:Telomerase is a ribonucleoprotein enzyme that catalyses the addition of telomeric repeats to telomeres. Since the shortening of telomeres is thought to act as a mitotic clock, activation of telomerase is crucial for the continued growth of cancer cells. Telomerase is frequently activated in premalignant and malignant ...

journal_title：Journal of dermatological science

authors： Ueda M

更新日期：2000-03-01 00:00:00

abstract：:Telomeres, which exist in eukaryotic chromosome ends in specialized G-rich TTAGGG structure, protect the ends from degradation or fusion. On the other hand, telomerase is a ribonucleoprotein complex enzyme that synthesizes TTAGGG repeat sequences at the ends of eukaryotic chromosomes. Previous studies suggested that t...

journal_title：Journal of dermatological science

authors： Matsui M,Miyasaka J,Hamada K,Ogawa Y,Hiramoto M,Fujimori R,Aioi A

更新日期：2000-02-01 00:00:00

abstract：:We previously reported a simple and easy-to-use device, Scratch Monitor for evaluation of nocturnal scratching. In the present study, the effect of an antihistamine (azelastine hydrochloride) on atopic dermatitis was investigated using this device. In 40 patients with atopic dermatitis, nocturnal scratching was measur...

journal_title：Journal of dermatological science

authors： Endo K,Sano H,Fukuzumi T,Adachi J,Aoki T

更新日期：1999-12-01 00:00:00

abstract：:Autoantibodies to human carbonic anhydrase II (CAII) were screened by ELISA in 109 sera from Asian Japanese patients with systemic lupus erythematosus (SLE), primary Sjögren's syndrome (Sjs), progressive systemic sclerosis (PSS) and dermatomyositis (DM). Anti-CAII antibodies were positive in 24.1% of SLE, 20.0% of pri...

journal_title：Journal of dermatological science

authors： Ono M,Ono M,Watanabe K,Miyashita Y,Inagaki Y,Ueki H

更新日期：1999-11-01 00:00:00

abstract：:Citrulline residues are detected in keratins and filaggrin in the cornified layers of mammalian epidermis. Such citrulline residues are formed by the enzymatic deimination of arginine residues by peptidylarginine deiminases (EC 3.5.3.15). Major deiminated keratins are derived from keratin K1. Two arginine residues ide...

journal_title：Journal of dermatological science

authors： Senshu T,Akiyama K,Ishigami A,Nomura K

更新日期：1999-09-01 00:00:00

abstract：:Quinolone antibacterial agents, known to elicit photosensitive dermatitis as an adverse effect, have both phototoxicity and photoallergenicity. The latter potency is mainly derived from their photohaptenic moiety; quinolones covalently bind to protein and cells upon exposure to ultraviolet A (UVA) light. Our previous ...

journal_title：Journal of dermatological science

authors： Tokura Y,Seo N,Ohshima A,Yagi H,Furukawa F,Takigawa M

更新日期：1999-09-01 00:00:00

abstract：:Epimorphin was demonstrated to be a mesenchymal signal factor modulating epithelial morphogenesis of skin, lung and liver in vitro. Most of the previous studies were performed biochemically and functionally. In the present study, expression of epimorphin was immunohistochemically compared between cultured fibroblasts ...

journal_title：Journal of dermatological science

authors： Zhang L,Ishikawa O,Takeuchi Y,Yokoyama Y,Miyachi Y

更新日期：1999-07-01 00:00:00

abstract：:Serum levels of sIL-2R can be used to monitor in vivo immune activation and its elevation have been shown to be correlated with T cell mediated immune disease such as atopic dermatitis, psoriasis, lymphoma and systemic sclerosis. Vitiligo is the disease of depigmentation caused by destruction of melanocytes, and there...

journal_title：Journal of dermatological science

authors： Yeo UC,Yang YS,Park KB,Sung HT,Jung SY,Lee ES,Shin MH

更新日期：1999-04-01 00:00:00

abstract：:Photochemotherapy using methoxsalen in combination with long-wave ultraviolet light (PUVA) is an essential modality in the treatment of various skin diseases. Major therapeutic regimens include oral, topical and water-delivery methods. An adequate regimen should be chosen regarding cases of disease, extent of involvem...

journal_title：Journal of dermatological science

authors： Danno K

更新日期：1999-02-01 00:00:00

abstract：:We isolated 73 streptococcus strains (41 from infections, and 32 from colonization) from various skin diseases between March, 1994, and June, 1998. In 29 out of 41 cases of infective origin, Staphylococcus aureus strains were simultaneously isolated. Twenty-four out of 28 patients with impetigo were suffering from ato...

journal_title：Journal of dermatological science

authors： Akiyama H,Yamasaki O,Kanzaki H,Tada J,Arata J

更新日期：1999-01-01 00:00:00

abstract：UNLABELLED:The percutaneous absorption studies were performed using a flow-through diffusion cell system with skin specimens from 24 healthy women to assess the penetration of glycolic acid (GA). Percentages of GA, based on 14C-labelled activity, found in the skin after application of 4% GA at pH 2.0 or pH 3.8, after 2...

journal_title：Journal of dermatological science

authors： Jiang M,Qureshi SA

更新日期：1998-12-01 00:00:00

abstract：:We investigated the adherence characteristics of Staphylococcus aureus and coagulase-negative staphylococci (CNS) isolated from various skin lesions by examining hydrophobicity, negative charge, tube adherence, slime production, and promotion of adherence to coverslips by blood proteins. Our results in the present stu...

journal_title：Journal of dermatological science

authors： Akiyama H,Yamasaki O,Kanzaki H,Tada J,Arata J

更新日期：1998-11-01 00:00:00

abstract：:Tauroursodeoxycholic acid (TUDC) is one of the most hydrophilic taurin conjugated bile acids. TUDC has a suppressive effect on DNA synthesis in primary cultured rat hepatocytes. In this study, we investigated the growth inhibitory effect of TUDC on cultured human keratinocytes. TUDC suppressed the proliferation of ker...

journal_title：Journal of dermatological science

authors： Yamaguchi Y,Itami S,Nishida K,Ando Y,Okamoto S,Hosokawa K,Yoshikawa K

更新日期：1998-09-01 00:00:00

abstract：:The immunomodulatory effect of the macrolide antibiotic, roxithromycin (RXM) on Langerhans cells (LC) was studied in mice. RXM inhibited the ability of LC to present superantigen and hapten to T cells at 100 microM. The superantigen-presenting activity of LC was more profoundly abrogated by RXM than the hapten-present...

journal_title：Journal of dermatological science

authors： Ohshima A,Tokura Y,Wakita H,Furukawa F,Takigawa M

更新日期：1998-07-01 00:00:00

abstract：:In order to know the possible effects of gastrin releasing peptide (GRP) on nevus cells and melanocytes, we studied the effect of GRP on the proliferation of cultured human nevus cells and normal melanocytes. MTS assay showed that GRP stimulated the growth of viable melanocytes at 1000 ng/ml. GRP also stimulated the g...

journal_title：Journal of dermatological science

authors： Terashi H,Itami S,Tadokoro T,Takeyama M,Katagiri K,Takayasu S

更新日期：1998-06-01 00:00:00

abstract：:Skin hyperpigmentation and itching are characteristic findings in systemic sclerosis (SSC) patients. Stem cell factor (SCF, c-kit ligand) is a multifunctional cytokine which can promote melanocyte and mast cell development. We investigated the SCF expression histopathologically in normal and SSC skin, and compared the...

journal_title：Journal of dermatological science

authors： Kihira C,Mizutani H,Asahi K,Hamanaka H,Shimizu M

更新日期：1998-05-01 00:00:00

abstract：:Psoriatic involved epidermis has been characterized by a defective beta-adrenergic adenylate cyclase response. It is also characterized by increased cholera toxin- and forskolin-induced cyclic AMP accumulations. Due to the fact that receptor signals are transduced to adenylate cyclase through guanine nucleotides bindi...

journal_title：Journal of dermatological science

authors： Tamura T,Takahashi H,Ishida-Yamamoto A,Hashimoto Y,Iizuka H

更新日期：1998-05-01 00:00:00

abstract：:The ability of beta-carotene, lutein or astaxanthin to protect against UVA-induced oxidative stress in rat kidney fibroblasts (NRK) was assessed. Activities of the antioxidant enzymes catalase (CAT) and superoxide dismutase (SOD), and changes in thiobarbituric acid reactive substances (TBARS) were measured as indices ...

journal_title：Journal of dermatological science

authors： O'Connor I,O'Brien N

更新日期：1998-03-01 00:00:00

abstract：:A cell line, designated ISOS-1, was established from a tumor formed by transplantation of a human angiosarcoma into mice with severe combined immunodeficiency (SCID). The cells showed endothelial properties, based on the uptake of Dil-Ac-LDL and binding of UEA-I/GSA-I lectins, but were negative for CD11b and Pan Cytok...

journal_title：Journal of dermatological science

authors： Masuzawa M,Fujimura T,Tsubokawa M,Nishiyama S,Katsuoka K,Terada E,Kunita S,Sakurai Y,Kato H

更新日期：1998-01-01 00:00:00

abstract：:We developed a new method for evaluating clinical symptoms of psoriasis during the observation period, by adding a parameter of time (the number of days) to the psoriasis area and severity index (PASI). This method was named the evaluation for prognosis with averaged PASI (E-PAP). Using this method, we assessed 14 cas...

journal_title：Journal of dermatological science

authors： Sugai J,Ozawa A,Kawakubo Y,Iizuka M,Miyahara M,Ohkido M

更新日期：1998-01-01 00:00:00